The focus of this paper is to uncover the potential part of therapeutically targeting FAK in the regulation of cell morphogenesis for cancer repair. For the reason that it focuses and introduces developmental morphogenesis and cancer morphogenesis, this article is relevant in today’s modern studies and technology. The significance of morphogenetic fields explains how tumor cells evolve normal-looking morphologies and function properly in the host. I believe that, with today’s cutting- edge technology and research, the damage that cancer causes will be reversed in the near future. The motor in mouse fibroblasts, dynein is thought to control the position of the centrosome by pushing on microtubules from the cell leading edge, where the motor is abundant during migration., according to this article. Fibroblasts are the most prevalent connective tissue cell type found throughout the body, and they are the primary source of the extracellular matrix (ECM) present in these tissues. Collagen proteins are secreted by fibroblasts and are utilized tommm maintain the structural foundation of numerous tissues. They are crucial in the healing of wounds. Dynein is a minus-end directed microtubule motor protein that uses ATP to propel its movement along microtubules tracks to deliver a variety of intercellular payloads. Cilia and flagella contain axon email dynein, whereas mammalian cells contain cytoplasmic dynein. Dynein delivers numerous cellular cargos, provides stresses and displacements needed in mitosis, and drives cilia and flagella beats in eukaryotes. Dynein is involved in a variety of biological activities by generating force and movement on microtubules. A small tubular structure found in the cytoplasm of cells that can clump together to form a more complicated structure. To deduce this summation, it’s still a mystery how dynein is attached at the cell’s leading edge. The interaction of the focal adhesion proteins FAK and paxillin with dynein in endothelium and NRK cells present an interesting possibility. FAK has also been shown to be necessary for appropriate centrosome placement in mouse fibroblasts and other cell types. However, it is currently unknown if dynein
interacts with FAK and paxillin in fibroblasts, and the role of these interactions during polarization has never been explored.